RT by @paulg: I just sequenced a human genome to 30× coverage entirely at home. As far as I kno

I just sequenced a human genome to 30× coverage entirely at home.

As far as I know, this is the first time this has been done.

I didn’t step foot in a lab once. Every step - from saliva collection, to running the sequencer - took place in a single room with a dining table + kitchenette.

Six weeks ago, I had never done wet lab biology before.

I used an Oxford Nanopore P2 Solo - the only commercially available sequencing device portable enough to do 30x human genome sequencing at home.

Biggest takeaway - I could build something that combined software, hardware, and molecular biology far faster than I thought was possible.

I can name >100 specific instances where AI helped me solve a technical problem that would previously have blocked me because I lacked access to a domain expert.

For example: how do I save my sequencing run when my DNA extraction yield is 4x lower than I need it to be, and I have this limited set of reagents to hand?

To make this work, I had to navigate multiple disciplines:

- writing software to monitor sequencing runs and orchestrate remote GPU infra for basecalling

- learning + executing 5 hour long molecular biology protocols

- building a hardware device to quantify DNA concentration

Apologies for the hyperbole, but I feel super lucky to be living in 2026.

A few weeks ago I decided to sequence a human genome to 30x at home.

Then I actually did it. And I did it really quickly.

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